Fluorescence In Situ Hybridization (FISH) Analysis
Fluorescence In Situ Hybridization (FISH) is a powerful molecular/cytogenetic technique that utilizes a fluorescent-labeled DNA probe to ascertain the presence or absence of a particular segment of DNA. It can be used to confirm or rule out small chromosome deletions, and to characterize subtle, complex chromosome rearrangements in interphase or metaphase cells.
Currently Genetics Center offers FISH analysis for the following microdeletion syndromes: Angelman syndrome, Prader-Willi syndrome, DiGeorge sequence, Velocardiofacial syndrome, Williams syndrome, Miller-Dieker syndrome and Smith-Magenis syndrome. We also perform whole chromosome painting for small translocations that cannot be visualized by conventional G-banding techniques.
The Genetics Center FISH laboratory is also equipped to test for many types of leukemia. We offer BCR/ABL testing for the Philadelphia chromosome (t(9;22)), which is found in about 99% of patients with CML. We offer testing for inv(16) which is found in 23% of AML-M4Eo patients. We also can detect the 15;17 translocation, which is found in about 97% of patients with APL.
If there is a test you require which is not listed, please contact us and speak to our laboratory personnel about available options.
Congenital FISH Testing
1p36 deletion syndrome
4p16.3 (Wolf-hirschorn syndrome)
5p15.2 (Cri du chat syndrome)
7q11.23 (Williams syndrome)
15q11-13 (Prader-Willi or Angelman syndrome)
17p11.2 (Smith-Magenis syndrome)
17p13.3 (Miller-Dieker syndrome)
Xp22.3 (STS or X-linked ichthyosis)
Prenatal FISH Testing
Aneuploidy (13/21 and 18/X/Y)
Cep X/SRY (rarely)
B-Cell Acute Lymphoblastic Leukemia (ALL)
Cep 4, Cep 10, Cep 17
T-Cell Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Chronic Lymphocytic Leukemia (CLL)
Chronic Myelogenic Leukemia (CML)
Myelodysplastic Syndrome (MDS)
3q27 (BCL 6)